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Chemotherapy of sarcomas
Author(s) -
Wilbur Jordan R.,
Sutow Wataru W.,
Sullivan Margaret P.,
Gottlieb Jeffrey A.
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197508)36:2+<765::aid-cncr2820360822>3.0.co;2-1
Subject(s) - medicine , vincristine , chemotherapy , rhabdomyosarcoma , cyclophosphamide , radiation therapy , soft tissue , sarcoma , combination chemotherapy , oncology , soft tissue sarcoma , surgery , embryonal rhabdomyosarcoma , pathology
The development of intensive treatment techniques with combination chemotherapy, radiation, and selected surgery has produced dramatic improvements in the treatment of soft tissue sarcomas. This has been best demonstrated in the long‐term disease‐free survival of a majority of children with inoperable or metastatic embryonal rhabdomyosarcoma treated with VAC chemotherapy (vincristine, actinomycin D, and cyclophosphamide). The addition of adriamycin and imidazole carboxamide to the combination therapy program for adults with soft tissue sarcomas has resulted in significant improvements in their response rates as well.