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Improvement in delayed hypersensitivity in Hodgkin's disease with transfer factor: Lymphapheresis and cellular immune reactions of normal donors
Author(s) -
Khan Amanullah,
Hill Joseph M.,
Maclellan Ayten,
Loeb Ellen,
Hill Norwood O.,
Thaxton Simone
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197507)36:1<86::aid-cncr2820360103>3.0.co;2-3
Subject(s) - transfer factor , medicine , delayed hypersensitivity , immunology , immune system , disease
Passive transfer of delayed hypersensitivity was achieved, with normal transfer factor, in patients with Hodgkin's disease in remission. The cellular immune responses of the recipients improved. It is suggested that, in addition to specific effect the transfer factor (or factors) has a nonspecific effect causing improvement in the state of delayed hypersensitivity of the recipient in general. The average number of E‐rosette T lymphocytes was 46.3% after the transfer factor treatment in Hodgkin's disease. The control patients with Hodgkin's disease, not receiving transfer factor, had a value of 37.8%. Removal of 4.9 × 10 9 to 1.08 × 10 10 lymphocytes did not diminish the delayed hypersensitivity of the donor. Side effects attributable to transfer factor were not seen.