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“B” cell origin of malignant cells in a case of american burkitt's lymphoma characterization of cells from a pleural effusion
Author(s) -
Binder Richard A.,
Jencks Judith A.,
Chun Byungkyu,
Rath Charles E.
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197507)36:1<161::aid-cncr2820360114>3.0.co;2-p
Subject(s) - medicine , antigen , pleural effusion , malignant cells , antiserum , pathology , titer , lymphoma , burkitt's lymphoma , effusion , virus , virology , immunology , cancer , surgery
Ninety‐eight percent of the cells isolated from a malignant pleural effusion in a case of American Burkitt's lymphoma showed membrane fluorescence to antihuman IgM antisera, while only 2% of the cells formed spontaneous rosettes with sheep red blood cells. It is concluded that the Burkitt cells in the malignant effusion are derived from bursal equivalent lymphocytes. Epstein‐Barr (E‐B) viral titers to both viral capsule antigen and early antigen were not elevated. The significance of these findings is discussed.