Premium
Tolerance of the spinal cord of rats to irradiation with cyclotron‐accelerated helium ions
Author(s) -
Leith John T.,
Lewinsky Bernard S.,
Woodruff Kay H.,
Schilling Wolfgang A.,
Lyman John T.
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197506)35:6<1692::aid-cncr2820350631>3.0.co;2-m
Subject(s) - medicine , bragg peak , nuclear medicine , paralysis , irradiation , plateau (mathematics) , ionization chamber , ion , spinal cord , ionization , radiochemistry , surgery , chemistry , physics , organic chemistry , psychiatry , nuclear physics , mathematical analysis , mathematics
Spinal cords of rats were exposed to either single doses of helium ions ranging from 500 to 3500 rads, or to fractionated doses of helium ions ranging from 1330 to 6530 rads using 10 equal fractions given over 22 days. Both plateau and spread‐out Bragg peak regions of ionization were used. For single doses there was no difference between plateau or spread‐out Bragg peak ionization regions for production of paralysis; the tolerance dose for production of paralysis was about 1900 rads. For the fractionation experiment, there was also no difference between plateau or spread‐out Bragg peak ionization regions for production of paralysis; the tolerance dose was between 5220 and 6530 rads. Comparison of dose levels producing about 10% partial paralysis indicates that about 500 rads of dose is recovered between fractions. In both single dose and fractionated experiments, latency between onset of paralysis was between 20 to 24 weeks.