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The effect of age on the long‐term response of bone marrow to local fractionated irradiation
Author(s) -
Fishburn R. I.,
Dobelbower R. R.,
Patchefsky A. S.,
Leeper D. B.,
Kramer S.
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197506)35:6<1685::aid-cncr2820350630>3.0.co;2-h
Subject(s) - medicine , bone marrow , repopulation , weanling , irradiation , nuclear medicine , haematopoiesis , radiation therapy , physiology , stem cell , biology , physics , nuclear physics , genetics
The in‐field long‐term progressive response of bone marrow to localized fractionated radiation to the thoracic spine was observed in weanling and adult rats. Total dose levels were 1800, 3600, and 5400 rads given in daily fractions of 180 rads for 900 rads per week, to simulate the clinical setting. Animals were sacrificed at 4½, 6, 8, and 10 months after irradiation, and bone marrow from within the treated area was examined. The juvenile marrow repopulated to higher levels of cellularity and after higher doses of radiation than the adult. The degree of marrow depletion, time of repopulation, and ultimate level of repopulation after cessation of irradiation were all dependent on the total dose. Some of the suggested clinical implications include re‐evaluation of the lower doses given to children.