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Modification of radiation injury to normal tissues by chemotherapeutic agents
Author(s) -
Phillips Theodore L.,
Wharam Moody D.,
Margolis Lawrence W.
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197506)35:6<1678::aid-cncr2820350629>3.0.co;2-k
Subject(s) - medicine , radiation injury , chemotherapeutic drugs , cancer research , radiation therapy , cancer , surgery
Abstract The effects of several cancer chemotherapeutic agents on radiation damage to normal intestine, esophagus, and lung tissue were evaluated in LAF 1 mice using quantitive endpoints. In all tissues tested, actinomycin D increased injury and BCNU did not. In the intestine, adriamycin enhanced radiation damage more than any other agent. Bleomycin increased damage in the esophagus but not in the lung or intestine. Cyclophosphamide increased injury only in the lung, where vincristine caused minimal injury, and hydroxyurea, none. Only prednisolone caused significant radioprotection when given at the time of irradiation or at the time of expected death from pulmonary injury.