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Studies on ectopic ACTH‐producing tumors. II. Clinical and biochemical features of 30 cases
Author(s) -
Imura Hiroo,
Matsukura Shigeru,
Yamamoto Hironosuke,
Hirata Yukio,
Nakai Yoshikatsu,
Endo Jiro,
Tanaka Akira,
Nakamura Masuhisa
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197505)35:5<1430::aid-cncr2820350529>3.0.co;2-o
Subject(s) - medicine , cushingoid , achalasia , cushing syndrome , pathology , esophagus , hormone , adrenocortical carcinoma , endocrinology
This report describes the clinical and biochemical features of 30 cases of ectopic ACTH‐producing tumors diagnosed by the detection of ACTH in the tumor tissues. Several uncommon tumors, such as tumors of the esophagus, stomach, and larynx, were included in this series. None of the patients with bronchogenic carcinoma showed signs of classical Cushing's syndrome, whereas 7 of the remaining 13 patients with other tumors were Cushingoid in appearance. Adrenocortical hyperfunction was present in 61% at the first examination and developed during the course of the disease in 18% more. In the remaining patients (21%), adrenocortical function remained within normal limits. These results indicate that there exist ectopic ACTH‐producing tumors without clinical and biochemical sequelae of excess hormone. In some of the tumor extracts studied, MSH and CRF‐like activities and serotonin were detected. This suggests that multiple hormone production is not uncommon in ectopic ACTH‐producing tumors.