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Mesocolic lymph node histology is an important prognostic indicator for patients with carcinoma of the sigmoid colon: An immunomorphologic study
Author(s) -
Patt David J.,
Brynes Russell K.,
Vardiman James W.,
Coppleson L. Warwick
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197505)35:5<1388::aid-cncr2820350523>3.0.co;2-g
Subject(s) - lymph , germinal center , medicine , lymph node , histology , pathology , immune system , carcinoma , b cell , antibody , immunology
Histologic parameters which are thought to reflect either cell‐mediated (T cell) or humoral (B cell) immune responses in lymph nodes have been studied in regional lymph nodes draining carcinoma of the sigmoid colon. Patients whose lymph nodes show morphological evidence of cell‐mediated immunity, manifested either by an increased number of paracortical immunoblasts or sinus histiocytosis, survive significantly longer than those whose lymph nodes show no such changes. Patients whose lymph nodes show simultaneous paracortical activity and sinus histiocytosis have the best survival of all. Of this latter group, 11/13 (83%) are living without signs of recurrent tumor 5 or more years after surgery. Histologic parameters which suggest an antibody‐mediated immune response (germinal center activity) were not an important prognostic indicator. The occurrence of favorable lymph node histology does not appear to significantly correlate with the modified Duke's classification. Rather, the favorable changes allow selection of a large proportion of those patients within the various Duke's categories who are destined to become long‐term survivors.