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Biological markers in breast carcinoma. I. Incidence of abnormalities of CEA, HCG, three polyamines, and three minor nucleosides
Author(s) -
Tormey Douglass C.,
Waalkes T. Phillip,
Ahmann David,
Gehrke Charles W.,
Zumwatt Robert W.,
Snyder Jack,
Hansen Hans
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197504)35:4<1095::aid-cncr2820350412>3.0.co;2-7
Subject(s) - medicine , incidence (geometry) , breast carcinoma , carcinoma , oncology , breast cancer , gynecology , cancer , physics , optics
Patients with breast carcinoma were screened for abnormal concentrations of CEA, HCG, putrescine, spermidine, spermine, pseudouridine, N 2 , N 2 ‐dimethylguanosine, and 1‐methylinosine. Abnormal polyamine levels occurred in less than 15% of the patients. Among the nucleosides, N 2 , N 2 ‐dimethylguanosine was the most frequently abnormal, occurring in 57% of the patients with metastatic disease. CEA levels were abnormal in 30% of postoperative N+ patients and 74% of patients with metastatic disease, while HCG elevations were found in 45% and 50%, respectively. All the patients with one or more marker abnormalities could be detected by measuring only CEA, N 2 , N 2 ‐dimethylguanosine, and HCG. Among these three tests, a singular marker abnormality occurred in 35.8% of the patients, and all three tests were abnormal in 21.8% of the patients. The performance of these three tests in each patient revealed one or more abnormalities in 97% of the patients with metastatic disease, and 67% of the postoperative N+ patients.