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A multiple chemotherapeutic approach to the management of hepatoblastoma. A preliminary report
Author(s) -
Holton Ciiarlene P.,
Burrington John D.,
Hatch Edwin I.
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197504)35:4<1083::aid-cncr2820350410>3.0.co;2-k
Subject(s) - medicine , hepatoblastoma , vincristine , chemotherapy , stage (stratigraphy) , cyclophosphamide , metastasis , surgery , hepatocellular carcinoma , oncology , cancer , paleontology , biology
In 1970, a staging based on surgical resectability of hepatic tumors was devised. Adjuvant chemotherapy with vincristine, 5‐fluorouracil, and cyclophosphamide has been given to seven recent cases. Objectives of this study were to set up unified clinical staging and followup; to evaluate the effect of combination chemotherapy on survival in advanced disease; and to evaluate early adjunctive combination chemotherapy in surgically resectable lesions to, hopefully, prevent metastasis. Results to date in seven patients are: no change in the poor prognosis of the three female patients presenting with Stage 111‐IV hepatocellular carcinoma; the three males with Stage 1‐11 hepatoblastoma have done well and survive free of disease at 47 months, 44 months, and 28 months; one patient with hepatoblastoma had lung metastasis at diagnosis and died at 7 months with tumor. No toxicity was noted with the use of adjunctive combination chemotherapy following major hepatic resection.