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Long‐term remission in diffuse histiocytic lymphoma treated with combination sequential chemotherapy
Author(s) -
Berd David,
Cornog John,
Deconti Ronald C.,
Levitt Martin,
Bertino Joseph R.
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197504)35:4<1050::aid-cncr2820350406>3.0.co;2-f
Subject(s) - medicine , histiocyte , complete remission , chemotherapy , lymphoma , regimen , histiocytic sarcoma , diffuse large b cell lymphoma , spontaneous remission , surgery , pathology , alternative medicine
Seventeen patients with Stage III or IV reticulum cell sarcoma were treated with three cycles of a 5‐drug regimen between February, 1969 and December, 1970. Of the 17 patients, 9 attained a complete remission and 6 had a partial remission; 2 were considered unevaluable. Recently, the original biopsies from these patients were reclassified according to the criteria of Rappaport et al. 7 The results were: diffuse histiocytic—8; nodular histiocytic—2; diffuse mixed—2; nodular mixed—3; diffuse lymphocytic poorly differentiated—1; nodular lymphocytic poorly differentiated—1. Of the 8 patients with diffuse histiocytic lymphoma 6 attained complete remission, 1 had a partial remission, and 1 was unevaluable. One of the 6 with complete remission relapsed at 7 months and died 2 months later. However, the other 5 are alive and in continued unmaintained remission for 55 to 65 months.