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Promotion of experimental breast carcinoma in rats treated with extract of liver from rats with portacaval shunt
Author(s) -
Reichle Frederick A.,
Noval Joseph J.,
Reichle Rose Marie
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197503)35:3<631::aid-cncr2820350314>3.0.co;2-b
Subject(s) - portacaval shunt , medicine , portacaval anastomosis , dmba , liver cancer , breast cancer , breast carcinoma , endocrinology , carcinoma , shunt (medical) , hepatocellular carcinoma , cancer research , pathology , carcinogenesis , cancer , cirrhosis , portal hypertension
Liver homogenates or extracts of liver homogenates from rats in which portacaval shunt had been performed were found to have a significant growth‐promoting effect on 7,12 dimethyl (a) benzanthracene (DMBA)‐produced breast carcinoma in rats. Tumor potentiation was manifested by increased incidence of animals developing tumors, increased number of tumors, and increased tumor size, when compared with animals receiving injections of shunted or control liver. These observations suggest the existence of a tumor‐stimulating factor in liver from which portal blood has been completely and chronically diverted by portacaval shunt. The demonstration of tumor growth stimulating factor(s) present in shunted liver, together with previously reported observations of the modification of the growth of various types of tumors in animals with a portacaval shunt, suggests that the liver is capable of playing an important role in tumor‐host interactions. The portacaval shunt appears to be useful as a technique in elucidating ways that liver function may influence tumor growth.