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The management of pulmonary metastases in children with osteogenic sarcoma with surgical resection combined with chemotherapy
Author(s) -
Beattie Edward J.,
Martini Nael,
Rosen Gerald
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197503)35:3<618::aid-cncr2820350312>3.0.co;2-z
Subject(s) - medicine , chemotherapy , vincristine , sarcoma , cyclophosphamide , osteosarcoma , methotrexate , thoracotomy , doxorubicin , surgery , oncology , pathology
This report concerns a consecutive group of 10 children with metastatic osteogenic sarcoma treated with combined surgery and chemotherapy. Eight of 10 patients had thoracotomy prior to chemotherapy, and 2 after an initial trial of chemotherapy. Sequential chemotherapy was given to all patients and consisted of vincristine, high‐dose methotrexate with citrovorum factor rescue, cyclophosphamide, and Adriamycin. Chemotherapy was continuously recycled for 1 year. The encouraging results obtained with these 10 patients are demonstrated with emphasis on the value of aggressive multidisciplinary therapy in salvaging patients with advanced metastatic osteogenic sarcoma.