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Leukemia in chiladhood: Introduction and etiology
Author(s) -
Hartmann John R.
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197503)35:3+<996::aid-cncr2820350722>3.0.co;2-a
Subject(s) - medicine , etiology , leukemia , bone marrow transplantation , chemotherapy , disease , childhood leukemia , bone marrow , transplantation , oncology , pediatrics , lymphoblastic leukemia
Striking improvement in the treatment of certain childhood cancers during the past decade has resulted from a combined multidisciplinary approach utilizing surgery, irradiation, and chemotherapy early in the disease process. Early use of long‐term combination chemotherapy following definitive clinical and hematologic staging has resulted in significant “cure” rates in several diseases. The etiology of childhood leukemia remains unknown. Implicated have been viruses, genetic abnormalities leading to increased susceptibility, exposure to various chemicals, and at times obscure hereditary or familial factors. The recurrence of leukemia in donor cells in a leukemic child following bone marrow transplantation is reported for the second time.