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Advances in the treatment of Wilms' tumor
Author(s) -
Wolff James A.
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197503)35:3+<901::aid-cncr2820350707>3.0.co;2-l
Subject(s) - medicine , vincristine , wilms' tumor , radiation therapy , chemotherapy , oncology , drug , dactinomycin , disease , surgery , pharmacology , cyclophosphamide , biology , cycloheximide , microbiology and biotechnology , protein biosynthesis
The addition of chemotherapy to older standard treatment with surgery and radiotherapy has increased survival to more than 80% in localized Wilms' tumor, and about 50% in metastatic disease. Actinomycin‐D and vincristine have proved to be the two most active agents. Multiple‐course maintenance treatment with actinomycin‐D has allowed fewer relapses, but not a significantly different survival rate than a single course of this drug. Use of actinomycin‐D and vincristinc in combination has been under study; initial indications show that the combination is superior to either drug employed singly. The need for postoperative radiotherapy in totally resected tumors confined to the kidney is also under study. Adriamycin is at present the most encouraging new drug that has had clinical trial.