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Combined modality therapy of acute lymphocytic leukemia
Author(s) -
Simone Joseph V.,
Aur Rhomes J. A.,
Hustu H. Omar,
Verzosa Manuel,
Pinkel Donald
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197501)35:1<25::aid-cncr2820350105>3.0.co;2-s
Subject(s) - medicine , leukemia , disease , chronic lymphocytic leukemia , modality (human–computer interaction) , intensive care medicine , acute lymphocytic leukemia , oncology , stage (stratigraphy) , treatment modality , lymphoblastic leukemia , paleontology , human–computer interaction , computer science , biology
The progressive improvement in the prognosis of acute lymphocytic leukemia has been a result of two major developments: 1) the more efficient use of chemotherapeutic agents, particularly the use of combinations of agents and the discovery that agents effective at one stage of disease may be inappropriate at another stage, and 2) the prevention with irradiation of central nervous system relapse. As many as one‐half of children with this disease may enjoy long‐term leukemia‐free survival. However, further studies are needed to improve the efficacy and reduce the toxicity of therapy. This paper reviews the evolution of some of these studies.