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On the frequency of tumor induction in a thorotrast kidney
Author(s) -
Verhaak R. L. O. M.,
Harmsen A. E.,
Van Unnik A. J. M.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197412)34:6<2061::aid-cncr2820340627>3.0.co;2-9
Subject(s) - thorotrast , medicine , renal pelvis , pyelogram , pelvis , kidney , radiology , urology , pathology
We have traced a group of 10 patients with Thorotrast kidney who underwent pyelography with Thorotrast in the early 1930s. An invasive carcinoma of the renal pelvis developed in 4 of them, diagnosed 21, 27, 32, and 34 years after Thorotrast pyelography. In 1 patient we found a carcinoma in situ of the renal pelvis after a latency of 35 years, and in 3 patients (35, 35, and 37 years after pyelography) the epithelium of the renal pelvis was dysplastic and metaplastic. Only in 2 patients of this group were no epithelial abnormalities found, after 24 and 25 years.