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Effects of bleomycin on cells in culture: A quantitative cytochemical study
Author(s) -
Desai L. S.,
Krishan A.,
Foley G. E.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197412)34:6<1873::aid-cncr2820340603>3.0.co;2-u
Subject(s) - endoreduplication , bleomycin , multinucleate , cell division , dna , cell culture , dna synthesis , microbiology and biotechnology , cell , biology , pathology , medicine , cell cycle , biochemistry , genetics , chemotherapy
Bleomycin‐treated mouse L‐929 fibroblasts are large in size and often appear multinucleated. Quantitative cytochemical studies show that these cells have an increased content of DNA and total proteins (dry mass) per cell. The increased accumulation of DNA and protein content (4–8C or more) is compatible with and may well be related to the bleomycin‐induced inhibition of cell division and the resulting endoreduplication.