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Blastic crisis in chronic granulocytic leukemia: Experience in 39 patients
Author(s) -
Vallejos Carlos S.,
Trujillo José M.,
Cork Ann,
Bodey Gerald P.,
McCredie Kenneth B.,
Freireich Emil J
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197411)34:5<1806::aid-cncr2820340531>3.0.co;2-1
Subject(s) - chronic granulocytic leukemia , medicine , acute leukemia , leukemia , chemotherapy , drug , complete remission , disease , oncology , pharmacology
In an attempt to prolong survival, a group of 39 adult patients with chronic granulocytic leukemia in acute transformation was treated with intensive chemotherapy regimens which included the use of single agents or drug combinations. An over‐all remission rate of 28% was obtained, with only 10% of the patients achieving complete remission. The cytogenetic profiles obtained during the acute phase of the disease were correlated with the clinical findings and the response to therapy. The results presented in this report indicate that, even with the use of modern therapeutic drugs, once chronic granulocytic leukemia enters a phase of acute transformation, the prognosis is equally poor for both Ph 1 negative and Ph 1 positive patients.