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Adamantinomas of long bones
Author(s) -
Unni Krishnan K.,
Dahlin David C.,
Beabout John W.,
Ivins John C.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197411)34:5<1796::aid-cncr2820340530>3.0.co;2-z
Subject(s) - medicine , fibula , amputation , fibrous dysplasia , tibia , adamantinoma , biopsy , radiodensity , surgery , anatomy , pathology , radiography , maxilla , ameloblastoma
A clinicopathologic study of 29 adamantinomas of long bones revealed that 26 were in the tibia; 3 of these also involved the adjacent fibula. Adamantinomas occurred twice as often in males as in females. Most of the patients were in the second and third decades of life. The symptoms were remarkable for their long duration. The commonest roentgenographic finding was that of multiple lucent zones interspersed with sclerotic bone, usually with one large rarefied area in the midshaft. Histologically, islands of epithelial cells with peripheral palisading were seen in a fibrous stroma. Tissue from peripheral radiolucent zones often mimicked fibrous dysplasia. Electron microscopy in 3 tumors provided evidence that the islands of cells were epithelial. Primary treatment consisted of excision in 8 cases, resection in 10, and amputation in 8; in 2 cases, the treatment was not known, and in 1, biopsy only was done. Only 3 patients died of their disease. Sixteen patients were alive without disease from 10 months to 32 years after treatment. Our results indicate that, when technically feasible, resection of the tumor is the treatment of choice for adamantinomas of the long bones.