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Distribution pattern of several enzymes of platelets under normal and leukemic conditions
Author(s) -
Ray Biswajit,
Basu Bani,
Bhattacharya Dilip K.,
Chatterjee Gora C.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197411)34:5<1756::aid-cncr2820340525>3.0.co;2-p
Subject(s) - acid phosphatase , platelet , enzyme , alkaline phosphatase , biochemistry , lysosome , leukemia , succinate dehydrogenase , intracellular , phosphatase , glucuronidase , dehydrogenase , distribution (mathematics) , chemistry , biology , immunology , mathematical analysis , mathematics
Intracellular distribution of certain enzymes such as acid phosphatase, alkaline phosphatase, β‐glucuronidase, and succinate dehydrogenase in isolated normal and leukemic platelets has been determined. Platelet alkaline phosphatase activity in any fraction studied is not changed under leukemic conditions. Increase of acid phosphatase and β‐glucuronidase and decrease of succinate dehydrogenase activities are observed in the leukemic platelet homogenate and in other fractions. Specific activities of lysosomal enzymes are decreased in lysosome free supernatant fraction under leukemic conditions. It is noted that normal platelet lysosomes are more labile than leukemic platelet lysosomes. The controlling system of the enzyme activities in platelets differs from that of the leukocytes under conditions of leukemia.