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Lymphomatoid granulomatosis of the skin: Light microscopic and ultrastructural studies
Author(s) -
Kay Saul,
Fu YaoShi,
Minars Norman,
Brady J. W.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197411)34:5<1675::aid-cncr2820340515>3.0.co;2-u
Subject(s) - histiocyte , medicine , pathology , dermis , lymphomatoid granulomatosis , vasculitis , sarcoidosis , dermatology , lymphoma , disease
A case of lymphomatoid granulomatosis involving the lung and skin (Liebow's disease) in a 71‐year‐old man is presented. The principal symptomatic features consisted of cutaneous involvement of the lower extremities. Secondary pseudomonas infection ultimately led to a below‐the‐knee amputation of the left leg. Several biopsies of the skin were studied with the light and electron microscope. The dermis showed a vasculitis with focal and diffuse infiltrations of pleomorphic cells, predominantely of the reticulohistiocytic group. The histiocytes showed variable degrees of differentiation; some appeared to be distinctly neoplastic rather than reactive. The cells seem to be different from mycosis cells as well as from those histiocytes encountered in histiocytosis X.