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Split‐course irradiation compared to split‐course irradiation plus hydroxyurea in inoperable bronchogenic carcinoma—a randomized study of 53 patients
Author(s) -
Landgren Robert C.,
Hussey David H.,
Barkley H. Thomas,
Samuels Melvin L.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197411)34:5<1598::aid-cncr2820340506>3.0.co;2-k
Subject(s) - medicine , irradiation , randomized controlled trial , bronchogenic carcinoma , surgery , carcinoma , nuclear medicine , physics , nuclear physics
Fifty‐three patients with inoperable but regionally localized non‐oat cell bronchogenic carcinoma were evaluated in a prospective randomized study of the use of split‐course irradiation alone and split‐course irradiation used in conjunction with hydroxyurea. The 25 patients receiving irradiation alone had 1‐ and 2‐year absolute survivals of 48% and 12% respectively, whereas the 28 patients receiving irradiation plus hydroxyurea had 46% 1‐year and 11% 2‐year survivals. Survival in the split‐course irradiation group was comparable at 2 years to that in a previous, similar group of patients irradiated continuously, but slightly inferior in terms of long‐term survivors. The split‐course rest period affords important patient observation time, permitting the elimination of unnecessary further irradiation in those patients who develop early distant metastases.