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A review of transfer factor immunotherapy in cancer
Author(s) -
Lobuglio Albert F.,
Neidhart James A.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197410)34:8+<1563::aid-cncr2820340831>3.0.co;2-s
Subject(s) - medicine , immunotherapy , cancer , transfer factor , cancer immunotherapy , oncology , immunology
Transfer factor is a small molecular weight material derived from peripheral blood leukocytes which has been shown to have the capacity to transfer cellular immunity from an immune donor to a nonimmune recipient. Considerable problems exist in the application of this material to human cancer, but preliminary studies suggest that transfer factor lacks significant toxicity and may be able to improve cellular immunity to tumor‐associated antigens as determined by in vitro assays. A few anecdotal reports in patients with advanced cancer suggest that it may have in vivo antitumor effects but adequate clinical trials have not yet been accomplished to determine clinical efficacy. Recent techniques for isolation and quantitation of the biologically active component of transfer will aid the design and accomplishment of future clinical trials.