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Immunotherapy of guinea pig cancer with bcg
Author(s) -
Zbar Berton,
Rapp Herbert J.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197410)34:8+<1532::aid-cncr2820340827>3.0.co;2-h
Subject(s) - medicine , guinea pig , new guinea , immunotherapy , cancer , bcg vaccine , cancer immunotherapy , immunology , vaccination , ethnology , history
An animal model for immunotherapy of cancer is described. Successful therapy required close contact between BCG and tumor cells, a host capable of developing and expressing delayed hypersensitivity type reactions to mycobacterial antigens, limited tumor size, and an adequate number of viable BCG. A nonliving mycobacterial preparation possessed potent tumor‐suppressive properties. This preparation, an oil in water emulsion, contained BCG cell walls attached to mineral droplets.