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Acute leukemia‐associated antigens
Author(s) -
Mann Dean L.,
Halterman Roger,
Leventhal Brigid
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197410)34:8+<1446::aid-cncr2820340816>3.0.co;2-b
Subject(s) - medicine , leukemia , antigen , immunology
Several investigators have demonstrated that antisera produced in heterologous animals by the injection of leukemia cells detect antigens associated with leukemia. In the studies reported here, antisera were raised by injecting rabbits with cell membrane components from a lymphoid tissue culture cell line, Raji, derived from a patient with Burkitt's lymphoma. This antiserum is cytotoxic to acute myelocytic and acute lymphocytic leukemia cells. Control studies indicate that this reactivity pattern is not against histocompatibility antigens. Clinical studies demonstrate that this antigen appears at the time of the acute phase of the disease and disappears from the cell surfaces as the patients are induced into remission with chemotherapy. In addition, substances blocking the reactivity of this antiserum have been found in the sera of patients with the acute phase of their disease. Human embryonic kidney cell lines do not express this antigen as detected by cytotoxicity and inhibition of cytotoxicity studies. However, when these cell lines are infected with the Rauscher leukemia virus, Kirsten virus, and the SV‐40 virus, the cells transform and the antigen appears on the cell surface. The consequences of the detection of this antigen or antigens in relationship to the clinical diagnosis and treatment of this disease as well as to etiologic agents are discussed.