Premium
Biochemical suppression of tumor virus activity
Author(s) -
Green Maurice,
Gerard Gary F.,
Grandgenett Duane P.,
Gurgo Corrado,
Rankin Anne M.,
Green Michael R.,
Cassell Douglas M.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197410)34:8+<1427::aid-cncr2820340814>3.0.co;2-g
Subject(s) - medicine , virus , virology
Abstract DNA and RNA polymerases and their templates play a central role in the control of gene expression. As an approach to a scientific chemotherapy to control nucleic acid‐directed disease, we have used the highly purified RNA‐directed DNA polymerase of the avian myeloblastosis virus (AMV) as a test enzyme to search for inhibitors of DNA polymerase. Three kinds of inhibitors with different mechanisms of action were studied: 1) rifamycin SV derivatives; 2) polycyclic amines; and 3) homopolymers composed of 2′O‐methyl and 2′‐O‐ethyl substituted poly(A), poly(U), poly(I), and poly(C). The biological activity in vitro and in vivo of these inhibitors and their mechanisms of action are discussed.