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Radiation therapy in the treatment of localized carcinoma of the prostate: Preliminary report using 22‐MeV photons
Author(s) -
Perez Carlos A.,
Ackerman Lauren V.,
Silber Igal,
Royce Robert K.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197410)34:4<1059::aid-cncr2820340415>3.0.co;2-8
Subject(s) - medicine , radiation therapy , prostate , pelvis , prostate cancer , hormonal therapy , metastasis , carcinoma , radiology , distant metastasis , localized disease , stage (stratigraphy) , oncology , urology , cancer , paleontology , biology
Preliminary results are reported with radical irradiation using 22‐MeV p photons in 59 patients with carcinoma of the prostate localized to the pelvis. All but 6 of the patients had extracapsular tumor extension (Stage C). This treatment technique appears to be effective in locally controlling the tumor, with low morbidity. After the 2nd year following treatment, the survival, clinically free of disease, is 50–60%. Approximately 15% of the patients have shown evidence of prostatic recurrence, frequently associated with distant metastasis. Of 11 patients in which postirradiation histologic sections of the prostate were reviewed, only 3 showed persistent microscopic tumor. Patients with poorly differentiated tumors had an extremely poor prognosis, a high proportion developing distant metastasis. Even though, at the present time, no definite statement can be made as to the effectiveness of radical irradiation alone in prolongation of survival of patients with carcinoma of the prostate clinically localized to the pelvis, it is imperative that this method of treatment be evaluated in controlled clinical trials with an option in which hormonal therapy will be deferred until progression of the disease or distant metastases develop.