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Radiation protection of the normal kidney by selective arterial infusions
Author(s) -
Steckel Richard J.,
Collins James D.,
Snow Harold D.,
Lagasse Leo D.,
Barenfus Morris,
Anderson Donald P.,
Weisenburger Thomas,
Hauskins Larry A.,
Ross Nancy A.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197410)34:4<1046::aid-cncr2820340414>3.0.co;2-l
Subject(s) - medicine , renal artery , superior mesenteric artery , epinephrine , kidney , balloon catheter , surgery , balloon , urology , anesthesia
Successful unilateral renal radioprotection has been attained in 10 of 18 experimental animals receiving protracted and fractionated radiation to large abdominal fields and unilateral renal artery epinephrine infusions, including 6 of the last 7 animals so treated. In a pilot series of patients with Stage III ovarian malignancies who were treated in a similar manner with unilateral renal artery epinephrine infusions, successful unilateral renal radioprotection has also been achieved in 3 out of 5 evaluable patients (the other 2 patients received potentially nephritic radiation doses to both kidneys, but have not in fact developed radiation nephritis on either side). In a series of 10 experimental animals, production of temporary unilateral renal hypoxia during abdominal irradiation by the use of a balloon occlusion catheter has not proved reliable in effecting unilateral renal radioprotection. However, in a subgroup of 5 animals, the data suggest that simultaneous infusion of a vasoconstrictor combination into the superior mesenteric artery during irradiation may prevent morbidity and mortality from acute radiation enteritis, under the experimental conditions employed.