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Normal pregnancy in multiple myeloma treated with cyclophosphamide
Author(s) -
Lergier Julio E.,
Jiménez Emilio,
Maldonado Norman,
Veray Francisco
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197410)34:4<1018::aid-cncr2820340409>3.0.co;2-4
Subject(s) - medicine , cyclophosphamide , pregnancy , multiple myeloma , obstetrics , fetal distress , fetus , chemotherapy , genetics , biology
We have studied a young woman with multiple myeloma who became pregnant while on oral cyclophosphamide. She had a normal pregnancy and was delivered by cesarean section because of fetal distress. The infant was healthy at birth and had an “M” component in serum of cord blood similar to his mother's. This abnormal protein disappeared when the infant was evaluated at 2 years of age. We conclude that the abnormal IgG in multiple myeloma can cross the placental barrier, but the newborn did not have any detectable disease. Chromosomal studies on the newborn were normal. Cyclophosphamide therapy produced no evident congenital abnormalities. A review of three additional instances of pregnancy and multiple myeloma is made, with a reveiw of the pertinent literature concerning pregnancy and cyclophosphamide therapy.