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An unusual case of canine osteosarcoma
Author(s) -
Pool R. R.,
Wolf H. G.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197409)34:3<771::aid-cncr2820340337>3.0.co;2-v
Subject(s) - osteosarcoma , osteoid , endoplasmic reticulum , pathology , golgi apparatus , karyotype , ultrastructure , medicine , anatomy , biology , microbiology and biotechnology , chromosome , genetics , gene
A spontaneous osteosarcoma in the limb of a dog had atypical histologic and ultrastructural appearances, and a hyperdyploid karyotype. Malignant cells aggregated into nodular structures, within which tumor osteoid was deposited. Tumor cells showed cytodifferentiation toward osteoblasts, with development of a relatively conspicuous rough endoplasmic reticulum and Golgi zones. Junctional contacts were commonly found between contiguous tumor cells. The finding of a hyperdyploid karyotype in component cells was in contradistinction to the reported hypodyploid state of canine osteosarcomas.