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Cytogenetic studies in mycosis fungoides
Author(s) -
ErkmanBalis Bayzar,
Rappaport Henry
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197409)34:3<626::aid-cncr2820340320>3.0.co;2-9
Subject(s) - mycosis fungoides , pathology , medicine , lymph , lymph node , bone marrow , lymphoma , lymphatic system , dermatology
Cytogenetic studies were performed in 11 patients with mycosis fungoides. The tissues examined consisted of skin, lymph node, spleen, bone marrow, and peripheral blood. All eleven cases including skin biopsies from four patients revealed abnormal karyotypes with a modal chromosome number ranging from 44 to 50. The chromosome abnormalities were consistent in each case. Multiple tissues taken from six cases, simultaneously and/or consecutively at time intervals ranging from 2.5 weeks to 1.5 years revealed, in each case, identical chromosome abnormalities which remained essentially unchanged over periods of up to 18 months. In 3 cases, cytogenetic studies were of additional help in the evaluation of the involvement of lymph nodes and bone marrow by mycosis fungoides at a time when histologic examination was negative or doubtful. Our observations are in keeping with the concept that mycosis fungoides is a neoplastic cutaneous disorder which may spread to extracutaneous tissues by lymphatic and hematogenous routes.