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Carcinoembryonic antigen by radioimmunoassay in the detection of recurrence during long‐term followup of female genital cancer
Author(s) -
Khoo S. K.,
Mackay E. V.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197409)34:3<542::aid-cncr2820340311>3.0.co;2-k
Subject(s) - carcinoembryonic antigen , medicine , radioimmunoassay , disease , cancer , cancer recurrence , gastroenterology
In the study, radioimmunoassay for carcinoembryonic antigen (CEA) was used in 75 patients with female genital cancer, who were followed up on a long‐term basis. These patients were assessed for the following disease status at each visit: free of disease, residual disease, or recurrence of disease. They also had periodic determinations of CEA in serum performed independently. The majority of patients who remained free of disease showed a rapid disappearance of CEA after treatment, whereas those who had residual disease continued to show persistence of CEA in serum. The patients who developed recurrence showed a re‐appearance of CEA after its initial disappearance; the mean time interval between re‐appearance of CEA and detection of clinical recurrence was 10.7 weeks. The CEA assay is considered to be a useful aid to the assessment of subsequent behavior of the tumor after primary treatment.