„solitary”︁ myeloma of bone a review of 12 cases

The clinical course and treatment of 12 patients with presumed solitary myeloma of bone are reviewed. These patients who presented with solitary lesions showed a rather protracted clinical course, often over many years, before disseminated myeloma became apparent. Three patients have been followed 5, 12, and 19 years respectively without definite evidence of multiple myeloma, although the latter patient has shown multiple solitary lesions. The eventual development of disseminated myeloma in the other 9 patients was preceded by a disease‐free interval of from 2 to 10 years following treatment of the solitary lesion.