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Human breast cancer and the autochthonous lymph node cell responses: A tissue culture and ultrastructural study
Author(s) -
Richters Arnis,
Sherwin Russell P.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197408)34:2<328::aid-cncr2820340217>3.0.co;2-#
Subject(s) - medicine , ultrastructure , lymph node , human breast , breast cancer , cancer , pathology , mammary gland , oncology
Tissue cultures of cancer‐free and cancer‐bearing lymph nodes from 52 breast cancer patients were studied by phase contrast microscopy and scanning as well as transmission electronmicroscopy, a first correlative report of a human autochthonous system. The distinctive characteristics of migratory and ameboid lymphocytes were confirmed, and ultrastructural details of inter‐relationships with target cells presented. Lymphocytes interact in many unique ways and through diverse spike‐free and spike‐bearing cytoplasmic processes, including uropod attachments. In this limited sampling, congregation was seen only with non‐neoplastic cells; associated abnormalities of the target cells were not detected. Migratory lymphocyte interactions were seen with both cancerous and non‐neoplastic cells.