Premium
Ultrastructural study of androgen‐producing adrenocortical adenoma
Author(s) -
Akhtar Mohammed,
Gosalbez Teresa,
Young Irving
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197408)34:2<322::aid-cncr2820340216>3.0.co;2-k
Subject(s) - ultrastructure , endoplasmic reticulum , adenoma , zona reticularis , pathology , adrenocortical adenoma , muscle hypertrophy , adrenal cortex , medicine , spironolactone , androgen , endocrinology , biology , zona glomerulosa , hormone , aldosterone , microbiology and biotechnology , angiotensin ii , blood pressure
Ultrastructural study of a virilizing adrenocortical adenoma from an 18‐year‐old girl revealed tumor cells with morphological features of cells of zona reticularis. Some of the cells contained laminated membranous inclusions identical to the so‐called spironolactone bodies. These bodies have not been previously described in any of the adrenal cortical tumors. It is suggested that these bodies represent exaggerated hypertrophy of smooth endoplasmic reticulum and are thus indicative of pronounced biosynthetic activity in the tumor cells.