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Effect of topical tubercidin on basal cell carcinomas and actinic keratoses
Author(s) -
Burgess Gordon H.,
Bloch Alexander,
Stoll Howard,
Milgrom Halena,
Helm Frederick,
Klein Edmund
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197408)34:2<250::aid-cncr2820340204>3.0.co;2-x
Subject(s) - actinic keratoses , medicine , basal (medicine) , dermatology , basal cell carcinoma , fluorouracil , basal cell , pathology , chemotherapy , insulin
The nucleoside Tubercidin was applied topically in a 0.5% concentration to solitary basal cell carcinomas in eight patients and widespread actinic keratoses in five patients for periods of 2–6 weeks. The treatment resulted in complete resolution of all eight basal cell carcinomas. All patients have been followed for 1 1/2 years. No recurrences have been observed. The treatment of the actinic keratoses was unsuccessful in four of five patients treated. These results are in contrast to those produced by topical 5‐fluorouracil, which is less active in basal cell carcinomas and more active against actinic keratoses than Tubercidin.