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Metastatic basal cell carcinoma: Review, report of a case, and chemotherapy
Author(s) -
Costanza Mary E.,
Dayal Yogeshwar,
Binder Sheldon,
Nathanson Larry
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197407)34:1<230::aid-cncr2820340134>3.0.co;2-2
Subject(s) - medicine , chemotherapy , basal cell carcinoma , metastasis , pathology , carcinoma , basal cell , basal (medicine) , lymph , lymph node , oncology , cancer , insulin
Basal cell carcinomas very rarely metastasize. A review of the literature revealed 90 documented cases of metastasizing basal cell carcinoma. Metastases occur most frequently to the regional lymph nodes (68%), while other sites such as bone, lungs, and liver are less frequently involved (less than 20%). We wish to report a case of metastasizing basal cell carcinoma and our experience with chemotherapy. Chemotherapy has been utilized in only three of the previously reported cases. To date a total of seven different cytotoxic agents has been tried; all have been unsuccessful. At present the drug of choice for metastasizing basal cell carcinoma awaits reports of successful treatment of metastasizing lesions; nevertheless, since the appearance of metastases in basal cell carcinoma carries an ominous prognosis (median survival of only 10 months), chemotherapy should be offered to these patients.