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Non‐Hodgkin's lymphomas. VI. Results of treatment in childhood
Author(s) -
Glatstein Eli,
Kim Hun,
Donaldson Sarah S.,
Dorfman Ronald F.,
Gribble T. John,
Wilbur Jordan R.,
Rosenberg Saul A.,
Kaplan Henry S.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197407)34:1<204::aid-cncr2820340131>3.0.co;2-2
Subject(s) - medicine , lymphoma , radiation therapy , stage (stratigraphy) , disease , histiocytosis , presentation (obstetrics) , histiocyte , retrospective cohort study , bone marrow , surgery , pathology , paleontology , biology
A retrospective study was undertaken reviewing records of all children seen in the Division of Radiation Therapy at Stanford University Hospital between 1961 and 1971 with a diagnosis of non‐Hodgkin's lymphoma. Of 41 patients who had been originally diagnosed as having a non‐Hodgkin's lymphoma, a diagnosis was confirmed in only 32. Two cases were interpreted as malignant histiocytosis, and 7 other patients were diagnosed as having Hodgkin's disease. Of the 32 patients with a non‐Hodgkin's lymphoma, all but 1 had lymphoma of the diffuse type, with diffuse histiocytic lymphoma being the most common histologic diagnosis. Lymphangiography was attempted in all but 1 patient. Fifty‐five percent of Stage I patients and 38% of Stage II patients are alive and free of disease more than 2 years after the completion of radiation therapy alone. There were no relapses seen after 12 months. Bone marrow involvement was seen in 5 patients at presentation and developed in an additional 8 patients following the initiation of radiation therapy.