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Para‐aortic lymph node irradiation in carcinoma of the uterine cervix
Author(s) -
Guthrie Robert T.,
Buchsbaum Herbert J.,
White A. J.,
Latourette Howard B.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197407)34:1<166::aid-cncr2820340125>3.0.co;2-j
Subject(s) - medicine , exploratory laparotomy , radiation therapy , lymph node , lymph , cervix , surgery , incidence (geometry) , stage (stratigraphy) , carcinoma , radiology , cancer , pathology , paleontology , physics , optics , biology
Patients with advanced carcinoma of the uterine cervix, Stages III and IV, received extensive pretreatment evaluations to assess the incidence of para‐aortic lymph node spread for this disease. A total of 40 patients was subjected to exploratory laparotomy for para‐aortic node biopsy. Involved para‐aortic nodes were found in 13/37 Stage III patients (35%) and 2/3 Stage IV patients. Of these 15 patients, 4 had other intraperitoneal spread, making them unsuitable for extended field radiation. Eleven patients received radiation to extended fields to cover para‐aortic lymph nodes. Anterior‐posterior Co., 60 ports were used, with a daily fraction of 180 rad, to a total of 5400 rad. This therapy was tolerated fairly well. Gastrointestinal problems were the most frequent immediate and late side‐effects. Of these patients, 10 completed all prescribed therapy. Five of these have died, at an average of 6.6 months following treatment; 5 are alive at 30, 21, 15, 15, and 5 months.