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Primary liver carcinoma
Author(s) -
Linder George T.,
Crook John N.,
Cohn Isidore
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197406)33:6<1624::aid-cncr2820330623>3.0.co;2-t
Subject(s) - medicine , jaundice , autopsy , hepatocellular carcinoma , anorexia , surgery , carcinoma , cirrhosis , abdominal pain , weight loss , obesity
From 1948 through 1970, 164 histologically diagnosed cases of primary liver carcinoma were managed at Charity Hospital in New Orleans. The disease was five times more common in males, and most frequently occurred in the 6th and 7th decades of life. Weight loss, upper abdominal pain, anorexia, and jaundice made up the most significant symptom complex. Hepatomegaly was the most common physical finding. Approximately 85% of the cases were hepatocellular carcinoma. Extra‐hepatic metastases were present in 55% of the 120 cases which came to autopsy. Lung, regional nodes, adrenals, and bone were the favored sites. Tumor was limited to one lobe in 32% of cases. Cirrhosis of the liver was diagnosed in 56%. Six patients underwent hepatic resection; 1 lived over 3 years, and 1 is alive 3 1/2 years after operation. Twelve patients received chemotherapy; 1 was alive at 2 1/2 years. Forty‐nine patients had an intra‐abdominal operative procedure. Over‐all survival data for operated vs. non‐operated cases did not vary significantly. Twenty‐seven patients had percutaneous liver biopsy; the death of 3 was directly attributable to intra‐abdominal hemorrhage after this procedure. Cancer 33:1624–1629, 1974.