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Hodgkin's disease of the thymus gland
Author(s) -
Keller Albert R.,
Castleman Benjamin
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197406)33:6<1615::aid-cncr2820330622>3.0.co;2-u
Subject(s) - medicine , nodular sclerosis , thymoma , pathology , mediastinum , myasthenia gravis , lymph , disease , diaphragm (acoustics) , anterior mediastinum , thymus neoplasm , lesion , lymphoma , anatomy , hodgkin lymphoma , physics , acoustics , loudspeaker
Forty‐four patients with Hodgkin's disease that was initially limited to the anterior mediastinum were studied by clinicopathologic analysis. In about half the cases there was involvement of the thymus gland, and in the other half there was involvement only of the anterior mediastinal lymph nodes. Evidence is presented that the thymic lesion, often called “granulomatous thymoma” 4 is in fact Hodgkin's disease of the thymus gland. All but 4 patients had the nodular‐sclerosis type of Hodgkin's disease, and in all the cases in which the thymus gland was involved, nodular sclerosis was found. The patients with thymic involvement were younger, with a male predominance. The 5‐year survival rate of 79% was similar whether or not the thymus gland was involved, and was comparable to reported cases of Stage I Hodgkin's disease elsewhere in the body. More than half the patients with followup observation have had recurrences, most of them above the diaphragm. Cancer 33:1615–1623, 1974.