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Spontaneous leukocyte oscillation during blastic crisis of chronic myeloid leukemia
Author(s) -
Mastrangelo Renato,
Stabile Achille,
Parenti Dante,
Segnis Giuseppe
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197406)33:6<1610::aid-cncr2820330621>3.0.co;2-b
Subject(s) - medicine , myeloid leukemia , leukemia , pathogenesis , blast crisis , immunology
A spontaneous oscillation of the peripheral‐blood leukocyte count was observed in a 7‐year‐old girl with chronic granulocytic leukemia in blastic crisis. The time interval between nadir and nadir of approximately 2 months was similar to that found in other patients with CGL studied prospectively during the chronic phase of the disease. The spontaneous fluctuation of the ultimately prevailing blastic stem line is consistent with the view that the leukemic cells of the blastic crisis may not be fully autonomous. Implications regarding pathogenesis and therapy of the blastic crisis are discussed. Cancer 33:1610–1614, 1974.