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Postmortem demonstration of abnormal deep pulmonary lymphatic pathways in lymphangitic carcinomatosis
Author(s) -
Hendin Alan S.,
Deveney Clifford W.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197406)33:6<1558::aid-cncr2820330613>3.0.co;2-i
Subject(s) - lymphatic system , medicine , lymph , pathology , lung , anatomy
Postmortem pulmonary lymphangiography was performed on a lung taken from a patient with extensive lymphangitic metastasis of a primary carcinoma of the urinary bladder. Abnormal, retrograde flow occurred into deep lymphatic branches. Valves in the deep lymphatics had become incompetent. The retrograde flow in lymphatics of lungs with lymphangitic carcinomatosis has not previously been described, to our knowledge. It may explain the presence of collateral lymph flow around obstructed pathways and probably facilitates generalized spread of tumor cells within the pulmonary lymphatics. Cancer 33:1558–1563, 1974.