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Multimodality cancer therapy in man: A pilot study of adriamycin by arterial infusion
Author(s) -
Haskell Charles M.,
Silverstein Melvin J.,
Rangel Decio M.,
Hunt John S.,
Sparks Frank C.,
Morton Donald L.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197406)33:6<1485::aid-cncr2820330602>3.0.co;2-v
Subject(s) - medicine , radiation therapy , infusion therapy , cancer , surgery , modality (human–computer interaction) , treatment modality , radiology , human–computer interaction , computer science
Adriamycin was given by an infra‐arterial route as part of a planned program of combined modality therapy in 10 patients with regionally advanced neoplasms. Doses ranged from 45–107 mg/m 2 given as a continuous infusion over 1.5–3.0 days. Adriamycin was followed by radiation therapy and/or radical surgical excision of the tumor in most cases, making long‐term evaluation of response difficult. However, 4 of 7 evaluable patients had prompt partial responses prior to subsequent treatment. We conclude that adriamycin can be administered by the intra‐arterial route and that it may be useful as part of a program of combined modality therapy in selected patients. Cancer 33:1485–1490, 1974.