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Incidence, cytology, and histopathology of non‐Hodgkin's lymphomas in the bone marrow
Author(s) -
Dick Fred,
Bloomfield Clara D.,
Brunning Richard D.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197405)33:5<1382::aid-cncr2820330525>3.0.co;2-2
Subject(s) - medicine , lymphoma , bone marrow , pathology , trephine , cytology , chronic lymphocytic leukemia , incidence (geometry) , leukemia , histopathology , physics , optics
Trephine and aspiration bone marrow biopsies were performed at time of initial diagnosis in 108 consecutive lymphoma patients. These have been evaluated to determine: 1) incidence, degree, and pattern of involvement; and 2) cytologic and histopathologic characteristics, for each type of lymphoma as classified by Rappaport. Forty cases exhibited marrow involvement. Nodular poorly‐differentiated lymphocytic lymphomas (PDLL‐N) more frequently exhibited marrow involvement than did diffuse poorly‐differentiated lymphocytic lymphomas (PDLL‐D) (p <.05). Study of cytology in blood and marrow smears and trephine imprints indicated that PDLL‐D is a diverse group with two relatively distinct subgroups: an intermediate differentiated form (idll) and a more poorly‐differentiated form (pdll). PDLL‐N is a more homogeneous group with a distinctive cell type—the hematogone‐like lymphocyte. While it may be difficult to differentiate lymphoma in the marrow from benign lymphocytic aggregates and lymphoma in the blood from lymphocytic leukemia, helpful distinguishing features exist.