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Carcinoid tumor of the pancreas. Ultrastructural observations of a lymph node metastasis and comparison with bronchial carcinoid
Author(s) -
Patchefsky Arthur S.,
Gordon Gloria,
Harrer William V.,
Hoch Willis S.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197405)33:5<1349::aid-cncr2820330520>3.0.co;2-0
Subject(s) - medicine , pathology , enterochromaffin cell , carcinoid syndrome , pancreas , carcinoid tumors , lymph node , gastrin , argentaffin , metastasis , ultrastructure , serotonin , cancer , secretion , receptor
The clinical, pathologic, and ultrastructural findings from the case of a 64‐year‐old woman with a malignant endocrine tumor of the pancreas are presented. Clinically, the carcinoid syndrome was absent; however, elevated levels of blood serotonin and urine 5‐HIAA were recorded. Serum insulin, gastrin, ACTH, cortisone, and aldosterone were normal. Histologically, the tumor was consistent with a carcinoid tumor. Argentaffin stains were strongly positive. Ultrastructurally, a supraclavicular lymph node metastasis contained pleomorphic secretory granules morphologically identical to those of enterochromaffin cells and carcinoid tumors of the gastrointestinal tract. Ultrastructural comparison with a pulmonary carcinoid tumor showed both to have identical pleomorphic secretory granules.