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Fine structure of human cervical intraepithelial neoplasia in vivo and in vitro
Author(s) -
Shingleton Hugh M.,
Wilbanks George D.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197404)33:4<981::aid-cncr2820330413>3.0.co;2-6
Subject(s) - cervical intraepithelial neoplasia , carcinoma in situ , pathology , in vivo , dysplasia , in vitro , medicine , ultrastructure , intraepithelial neoplasia , basal cell , koilocyte , cervical carcinoma , carcinoma , cervical cancer , biology , cancer , genetics , prostate
Abstract The fine structure of normal cervical squamous cells and cells of cervical intraepithelial neoplasia (CIN) from both biopsies and tissue culture was studied. The cultured CIN cells were found to retain their epithelial characteristics even after subculturing and to resemble in most aspects their in vivo counterparts; they were found to differ markedly from cultured normal squamous cells. It was not possible to distinguish “dysplasia” from “carcinoma‐in‐situ” at the ultrastructural level in either biopsies or cultured cells. This lends support to the concept that the two are part of a continuum, not separate entities. It would appear that cultures of normal cervical squamous cells and CIN cells may be useful for further study of the biology of cervical neoplasia.