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Management of the patient with early endometrial carcinoma
Author(s) -
Keller David,
Kempson Richard L.,
Levine Gerald,
McLennan Charles
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197404)33:4<1108::aid-cncr2820330433>3.0.co;2-a
Subject(s) - medicine , stage (stratigraphy) , carcinoma , myometrium , adenocarcinoma , radiation therapy , uterus , surgery , survival rate , cancer , paleontology , biology
One hundred forty sequential patients treated for endometrial adenocarcinoma between 1958 and 1966 at Stanford University Hospital are reported. The 5‐year actuarial survival for the group was 75%. Tumor recurrence and prognosis correlated with histologic differentiation and depth of myometrial invasion. Stage I patients treated with surgery alone had a 5‐year actuarial survival of 95% and a tumor recurrence rate of 2%. Routine preoperative irradiation does not appear to be necessary or logical in the treatment of Stage I endometrial carcinoma. Rather, postoperative radiation should be used for those Stage I patients whose tumors invade beyond 50% of the thickness of the myometrium as determined by pathologic examination of the uterus. Preoperative radiation therapy should be used for Stage II and III patients and possibly for Stage I patients with anaplastic carcinoma.