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Comparative incidence of bronchogenic carcinoma in subjects with centrilobular and panlobular emphysema
Author(s) -
Anderson A. E.,
Foraker Alvan G.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197404)33:4<1017::aid-cncr2820330417>3.0.co;2-5
Subject(s) - medicine , bronchogenic carcinoma , incidence (geometry) , carcinoma , lung cancer , pathology , physics , optics
Twenty‐one cases of centrilobular emphysema and nineteen cases of panlobular emphysema, all previously reported for morphological characteristics, were analyzed for the comparative incidence of bronchogenic carcinoma. Seven of the patients with centrilobular disease also had lung cancer, whereas, none of the patients with panlobular emphysema was so affected. These differences were statistically significant, suggesting a much closer tie between bronchogenic carcinoma and centrilobular emphysema than with panlobular disease. It was proposed that the frequent co‐existence of the two conditions reflected separate effects of a common agent, i.e. tobacco smoke.